Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm
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- 作者：Elisabeth Otta ; elisabeth.ott@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; Bjö ; rn Wendikb ; 2 ; bjoern.Wendik@PERKINELMER.COM" class="auth_mail" title="E-mail the corresponding author ; Monika Srivastavab ; 1 ; monika.srivastava@anu.edu.au" class="auth_mail" title="E-mail the corresponding author ; Frederic Pachoa ; frederic.pacho@uibk.ac.at" class="auth_mail" title="E-mail the corresponding author ; Sonja Tö ; chterlea ; Willi Salvenmoserc ; willi.salvenmoser@uibk.ac.at" class="auth_mail" title="E-mail the corresponding author ; Dirk Meyera ; dirk.meyer@uibk.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：mnx1 ; mnx2b ; irx1b ; Sacral agenesis ; Currarino syndrome ; Intermediate mesoderm ; Pronephros ; Zebrafish ; Development
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：411
- 期：1
- 页码：101-114
- 全文大小：20833 K
文摘
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Mnx2b is transiently expressed in caudal intermediate mesoderm.
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Mnx2b is required for pronephric tubule morphogenesis and function.
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Irx1b is a direct target of Mnx transcription factors.
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Mnx2b is required to prevent ectopic activation of Irx1b in the distal tubule.