Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance
详细信息 查看全文
- 作者：Heidi Bildsoea ; 1 ; heidi.bildsoe@monash.edu" class="auth_mail" title="E-mail the corresponding author ; Xiaochen Fana ; Emilie E. Wilkieb ; Ator Ashotia ; c ; Vanessa J. Jonesa ; Melinda Powera ; Jing Qind ; 2 ; qinjing@cuhk.edu.hk" class="auth_mail" title="E-mail the corresponding author ; Junwen Wangd ; 3 ; wang.junwen@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Patrick P.L. Tama ; David A.F. Loebela ; dloebel@cmri.org.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：bHLH factor ; Twist1 ; Extracellular matrix-cell interaction ; Mesenchyme ; Craniofacial ; Cranial mesoderm
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：418
- 期：1
- 页码：189-203
- 全文大小：11995 K
文摘
- •
TWIST1 controls cell-ECM interaction and mesenchyme genes in cranial mesoderm.
- •
We identified genes that are TWIST1-dependent and predominantly expressed in the mesoderm.
- •
ChIP-seq identified potential TWIST1-targets in a TWIST1-dependent mesenchymal cell model.
- •
Three transcriptional targets of TWIST1 (Ddr2, Pcolce and Tgfbi) were validated.