Impregnation of Fenofibrate on mesoporous silica using supercritical carbon dioxide
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- 作者：Abir Bouledjouidjaa ; abir.gch@hotmail.fr" class="auth_mail" title="E-mail the corresponding author ; abir.bouledjouidja@etu.univ-amu.fr" class="auth_mail" title="E-mail the corresponding author ; Yasmine Masmoudia ; yasmine.masmoudi@univ-amu.fr" class="auth_mail" title="E-mail the corresponding author ; Michiel Van Speybroeckb ; Laurent Schuellerb ; Elisabeth Badensa ; elisabeth.badens@univ-amu.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Supercritical fluids ; Soaking in liquid ; Ordered mesoporous silica (OMS-L-7) ; Fenofibrate ; Drug delivery system
- 刊名：International Journal of Pharmaceutics
- 出版年：2016
- 出版时间：29 February 2016
- 年：2016
- 卷：499
- 期：1-2
- 页码：1-9
- 全文大小：1339 K
文摘
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Loading of a poorly water-soluble drug, Fenofibrate, within an ordered-mesoporous silica using two different processes: incipient wetness and supercritical impregnation.
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High loading of Fenofibrate with a low degree of crystallinity for both impregnation processes.
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Higher impregnation yield in shorter impregnation duration obtained with supercritical impregnation process comparing to the incipient wetness.