Zooming-in on cancer metabolic rewiring with tissue specific constraint-based models
详细信息 查看全文
- 作者：Marzia Di Filippoa ; b ; Riccardo Colomboa ; b ; Chiara Damiania ; b ; Dario Pescinia ; c ; dario.pescini@unimib.it" class="auth_mail" title="E-mail the corresponding author ; Daniela Gaglioa ; e ; Marco Vanonia ; d ; Lilia Alberghinaa ; d ; Giancarlo Mauria ; b
- 关键词：Cancer metabolic rewiring ; Network reconstruction ; Core metabolic model ; Flux Balance Analysis
- 刊名：Computational Biology and Chemistry
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：62
- 期：Complete
- 页码：60-69
- 全文大小：843 K
文摘
- •
Genome-scale metabolic models are comprehensives but difficult to control and to analyze.
- •
We manually reconstructed core models that zoom-in on cancer metabolic rewiring, focusing on most harmful neoplasias.
- •
We estimated the optimal flux distribution for each of the core metabolic models with FBA.
- •
We observed heterogeneity in flux values between reference and cancer conditions, but also among the different cancers.
- •
We identified a set of reactions that is responsible for the reversion of cancer phenotype.