Non-alcoholic fatty liver disease with and without metabolic syndrome: Different long-term outcomes

详细信息    查看全文

• 作者：Aki Juhani Kä ; rä ; jä ; mä ; ki^a ; Risto Bloigu^b ; Heikki Kauma^a ; Y. Antero Kesä ; niemi^a ; Olli-Pekka Koivurova^a ; Juha Perkiö ; mä ; ki^a ; Heikki Huikuri^a ; Olavi Ukkola^a ; ^{olavi.ukkola@oulu.fi}
• 关键词：Non-alcoholic fatty liver disease ; Metabolic syndrome ; Type 2 diabetes ; Cardiovascular diseases
• 刊名：Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：66
• 期：Complete
• 页码：55-63
• 全文大小：414 K
• 卷排序：66

文摘

Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are both shown to increase the risk of cardiovascular diseases and type 2 diabetes. However, there is a great overlap between these two diseases. The present study was aimed to examine the cardiovascular and metabolic prognosis of non-alcoholic fatty liver disease with and without metabolic syndrome.MethodsMiddle-aged subjects (n = 958) were divided into four subgroups, those with NAFLD and MetS, those with NAFLD or MetS, and healthy controls. The baseline characteristics of the subgroups were analyzed. The follow-up time for cardiovascular events was about 16 years. After approximately 21 years the cardiac ultrasound and laboratory parameters were re-analyzed and new type 2 diabetes cases were recorded.ResultsThose with both diseases were at the greatest risk for cardiovascular events (p < 0.001). Compared to healthy controls, only those with MetS, with or without NAFLD, were at increased risk for the development of type 2 diabetes (p < 0.001) and for an increase in left ventricular mass index (p = 0.001 and p = 0.005, respectively). The cardiovascular and metabolic risk in subjects with NAFLD only was quite similar to that in healthy controls. The I148M variant of the patatin-like phospholipase domain-containing 3 gene (PNPLA3 polymorphism) was most present in those with NAFLD only (p = 0.008).ConclusionsNAFLD with MetS implies a considerable risk for cardiovascular diseases, type 2 diabetes and the increase of left ventricular mass index whereas NAFLD without MetS does not.