Mitochondria-Associated Membranes Response to Nutrient Availability and Role in Metabolic Diseases

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• 作者：Pierre Theurey¹ ; Jennifer Rieusset² ; ^{jennifer.rieusset@univ-lyon1.fr}
• 关键词：insulin resistance ; metabolic flexibility ; mitochondria-associated membrane ; organelle communication ; protein phosphatase 2A
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：28
• 期：1
• 页码：32-45
• 全文大小：2496 K
• 卷排序：28

文摘

Metabolic diseases are associated with nutrient excess and metabolic inflexibility. Mitochondria and endoplasmic reticulum are important organelles and nutrient sensors, and their dysfunction has been extensively and independently implicated in metabolic diseases. Both organelles interact at sites known as mitochondria-associated membranes (MAMs), in order to exchange metabolites and calcium. Recent evidence indicates that MAM could be a hub of hepatic insulin signaling and nutrient sensing. In this review, we discuss the roles organelle function and communication play in the cell's adaptation to nutrient availability, in both physiology and metabolic diseases. We highlight how dynamic regulation of MAM affects mitochondria physiology and adaptation of cellular metabolism to nutrient availability, and how chronic MAM disruption participates in the metabolic inflexibility associated with metabolic disorders.