文摘
Global IP6K1 deletion protects mice from DIO and insulin resistance, irrespective of environmental temperature conditions. Chow diet-fed IP6K1-KO mice expend more energy at 5 °C. High fat diet-fed IP6K1-KO mice oxidize more carbohydrate at 5 °C; whereas they oxidize more fat at 23 °C and 30 °C. Enhanced expression of UCP1, but not other EE markers, is partly impaired in high fat diet-fed IP6K1-KO mice at 30 °C. IP6K1 promotes cellular fat accumulation by diminishing AMPK mediated energy metabolism.