Tissue-dependent cerebral energy metabolism in adolescents with bipolar disorder
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- 作者：Jonathan Dudleya ; dudleyjd@ucmail.uc.edu" class="auth_mail" title="E-mail the corresponding author ; Melissa P. DelBellob ; Wade A. Weberb ; Caleb M. Adlera ; b ; Stephen M. Strakowskib ; c ; Jing-Huei Leea ; b ; c
- 关键词：Bipolar disorder ; Adolescent ; Bioenergetics ; 31P MRS
- 刊名：Journal of Affective Disorders
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：191
- 期：Complete
- 页码：248-255
- 全文大小：850 K
文摘
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31P MRS imaging data were acquired from adolescent bipolar disorder subjects.
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High energy phosphate levels were determined in homogeneous gray and white matter.
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For bipolar subjects: PCr decreased in gray matter, ATP decreased in white matter.
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Findings consistent with downregulation of creatine kinase.
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Further supports bioenergetic impairment in bipolar disorder.