Catalase deletion promotes prediabetic phenotype in mice

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• 作者：Claire Heit^a ; Stephanie Marshall^b ; Surrendra Singh^b ; Xiaoqing Yu^c ; Georgia Charkoftaki^b ; Hongyu Zhao^c ; David J. Orlicky^d ; Kristofer S. Fritz^a ; David C. Thompson^e ; Vasilis Vasiliou^b ; ^{vasilis.vasiliou@yale.edu}
• 关键词：Catalase ; Obesity ; Metabolism ; Steatosis ; Diabetes
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：48-56
• 全文大小：705 K
• 卷排序：103

文摘

Catalase activity is integral to the regulation of systemic nutrient metabolism. Catalase-deficient mice develop obesity and metabolic dysfunction on normal chow diet. RNA-seq analyses support a dysregulated, obese phenotype in catalase-deficient mice. Histopathologically, catalase-deficient mice are metabolically dysregulated and obese.