Impact on CYP19A1 activity by mutations in NADPH cytochrome P450 oxidoreductase

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• 作者：Christa E. Flü ; ck ; Amit V. Pandey ; ^{amit@pandeylab.org}
• 关键词：CYP19A1 ; NADPH P450 oxidoreductase ; Antely-Bixler syndrome ; Adrenal hyperplasia ; POR ; Steroid metabolism
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PA
• 页码：64-70
• 全文大小：1638 K
• 卷排序：165

文摘

Variations in POR affect multiple cytochrome P450 activities. Mutant POR affects CYP19A1 activities. CYP19A1 disruption due to POR mutations may cause disordered steroidogenesis.