Liquid chromatography separation of the chiral prodrug eslicarbazepine acetate and its main metabolites in polar organic mode. Application to their analysis after in vitro metabolism
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- 作者：Anne-Catherine Servais ; acservais@ulg.ac.be" class="auth_mail" title="E-mail the corresponding author ; Bertrand Janicot ; Arnold Takam ; Jacques Crommen ; Marianne Fillet
- 关键词：Eslicarbazepine acetate ; In vitro metabolites ; Liquid chromatography ; Chiral stationary phase
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：7 October 2016
- 年：2016
- 卷：1467
- 期：Complete
- 页码：306-311
- 全文大小：471 K
文摘
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A LC method was developed to separate chiral prodrug ESL and its main metabolites.
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Elution order reversal was observed, depending on the MeOH% in the mobile phase.
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LC in polar organic mode is a useful technique to study drug in vitro metabolism.