UHPLC-MS/MS method for the quantitation of penicillin G and metabolites in citrus fruit using internal standards

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• 作者：Daniele Canzani ; Kevin Hsieh ; Matthew Standland ; Walter Hammack ; Fadi Aldeek ; ^{fadi.aldeek@freshfromflorida.com}
• 关键词：Huanglongbing (HLB) ; Penicillin G ; Metabolites ; LC&ndash ; MS/MS ; Internal standards ; Method development
• 刊名：Journal of Chromatography B
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：1044-1045
• 期：Complete
• 页码：87-94
• 全文大小：1721 K
• 卷排序：1044

文摘

Development and validation of LC–MS/MS method to identify and quantitate penicillin G and two of its metabolites, penillic acid and penilloic acid, in citrus fruit. Improvement of a previous method by incorporating isotopically labeled internal standards, namely, penillic acid-D5, and penilloic acid-D5. Method enhancement and precision of measurements.