Diving for drugs: tunicate anticancer compounds

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• 作者：Edwin L. Cooper ; ^{cooper@mednet.ucla.edu} ; ^{dyao267@gmail.com} ; David Yao
• 刊名：Drug Discovery Today
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：17
• 期：11-12
• 页码：636-648
• 全文大小：613 K

文摘

The marine biosphere boasts tremendous biodiversity replete with structurally unique, active and selective secondary metabolites. Bioprospecting for antitumor compounds has been rewarding, and tunicates have been especially successful in yielding prospective cancer therapies. These compounds are now subjected to clinical trials in Europe and the USA. With the ongoing search for potent and specific anticancer drugs, in this article we discuss the unique perspectives, compounds and opportunities afforded by this rich source of potential pharmaceuticals. We discuss marine-derived antitumor drugs, their structures, and their various types and levels of antitumor activities in bench and bedside efforts.