Key role of an ADP − ribose - dependent transcriptional regulator of NAD metabolism for fitness and virulence of Pseudomonas aeruginosa

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• 作者：Elza Okon^a ; ¹ ; Sarah Dethlefsen^a ; Anna Pelnikevich^a ; ² ; Andrea van Barneveld^a ; Antje Munder^a ; ^b ; Burkhard Tü ; mmler^a ; ^b ; ^{tuemmler.burkhard@mh-hannover.de}
• 关键词：Airway infection model ; Fitness experiments ; Metabolome ; NAD biosynthesis ; Nudix protein ; Pseudomonas aeruginosa
• 刊名：International Journal of Medical Microbiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：307
• 期：1
• 页码：83-94
• 全文大小：2536 K
• 卷排序：307

文摘

PA4916-PA4920 encode salvage pathway I of NAD biosynthesis in Pseudomonas aeruginosa. PA4916 encodes the transcriptional repressor NrtR of salvage pathway I. Antirepressor ADP-ribose displaces NrtR from its intergenic binding site. PA4917 encodes the nicotinate mononucleotide adenylyltransferase NadD2. Inactivation of NrtR abrogates virulence and constrains fitness and metabolome.