Differential effects of N-acetyl-aspartyl-glutamate on synaptic and extrasynaptic NMDA receptors are subunit- and pH-dependent in the CA1 region of the mouse hippocampus
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- 作者：Pamela Khachoa ; Boyang Wanga ; Nina Ahlskoga ; Elitza Hristovaa ; Richard Bergerona ; b ; c ; rbergeron@ohri.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-PMPA ; 2-(phosphonomethyl)pentanedioic acid ; 2-PMSA ; 2-(phosphonomethyl)succinic acid ; ACSF ; artificial cerebrospinal fluid ; BDNF ; brain-derived neurotrophic factor ; CREB ; cAMP response element binding protein ; EPSC ; excitatory postsynaptic current ; GCP-II ; glutamate carboxypeptidase type II ; mGluR3 ; metabotropic glutamate receptor 3 ; NAAG ; N-acetyl-aspartyl-glutamate ; NMDAR ; N-methyl-d-aspartate receptor
- 刊名：Neurobiology of Disease
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：82
- 期：Complete
- 页码：580-592
- 全文大小：2070 K
文摘
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NAAG enhances synaptic and inhibits extrasynaptic NMDAR EPSCs in physiological pH.
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Acidic pH induces an inhibitory effect of NAAG on NMDAR currents.
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The effects of NAAG on NMDARs are subunit-dependent.
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NAAG increases surface expression of GluN2A-containing NMDARs in acidic conditions.