Intrinsic plasticity induced by group II metabotropic glutamate receptors via enhancement of high-threshold KV currents in sound localizing neurons
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- 作者：W.R. Hamlet&dagger ; ; Y. Lu ; ylu@neomed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACSF ; artificial cerebrospinal fluid ; AP ; action potential ; CF ; characteristic frequency ; GPCR ; G protein-coupled receptor ; HF ; high frequency ; HTK ; high-threshold potassium ; ITD ; interaural time difference ; KV ; voltage-gated potassium channel ; LF ; low frequency ; LTK ; low-threshold potassium ; mGluR ; metabotropic glutamate receptor ; MF ; middle frequency ; MNTB ; medial nucleus of trapezoid body ; NaV ; voltage-gated sodium channel ; NM ; nucleus magnocellularis ; NL ; nucleus laminaris ; PKC ; protein kina
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：324
- 期：Complete
- 页码：177-190
- 全文大小：1499 K
文摘
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Perforated patch clamp recordings revealed modulation of Kv channel currents in nucleus laminaris neurons.
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Group II metabotropic glutamate receptors mediated the modulation via signaling pathway involving PLC and PKC.
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The modulation was more pronounced in low-frequency than in middle- and high-frequency neurons.
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The modulation improved the ability of nucleus laminaris neurons to follow high-frequency inputs.