Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
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- 作者：Joong-Seok Kima ; neuronet@catholic.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Hyung-Eun Parka ; Yoon-Sang Ohb ; Si-Hoon Leea ; Jeong-Wook Parkc ; Byung-chul Sond ; Kwang-Soo Leea
- 关键词：Parkinson's disease ; Rapid eye movement sleep behavioral disorder (RBD) ; Orthostatic hypotension (OH) ; Cardiac sympathetic denervation ; 123I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：362
- 期：Complete
- 页码：59-63
- 全文大小：440 K
文摘
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RBD is closely related to OH and cardiac sympathetic denervation in mild PD.
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PD patients with OH also have decreased myocardial MIBG uptake.
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OH may lead to hypoperfusion, which disturb normal neurotransmitter functions.
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Impaired cardiac sympathetic innervation could be the mechanism behind OH.
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This association may be closely correlated with Braak alpha-synuclein sequences.