Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

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• 作者：Tejabhiram Yadavalli ; PhD^a ; ^b ; Deepak Shukla ; PhD^b ; ^c ; ^{dshukla@uic.edu}
• 关键词：Nanoparticle ; Metal and metal oxide ; Virus
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：13
• 期：1
• 页码：219-230
• 全文大小：967 K
• 卷排序：13

文摘

Nanotechnology is increasingly playing important roles in various fields including virology. The emerging use of metal or metal oxide nanoparticles in virus targeting formulations shows the promise of improved diagnostic or therapeutic ability of the agents while uniquely enhancing the prospects of targeted drug delivery. Although a number of nanoparticles varying in composition, size, shape, and surface properties have been approved for human use, the candidates being tested or approved for clinical diagnosis and treatment of viral infections are relatively less in number. Challenges remain in this domain due to a lack of essential knowledge regarding the in vivo comportment of nanoparticles during viral infections. This review provides a broad overview of recent advances in diagnostic, prophylactic and therapeutic applications of metal and metal oxide nanoparticles in human immunodeficiency virus, hepatitis virus, influenza virus and herpes virus infections. Types of nanoparticles commonly used and their broad applications have been explained in this review.