A critical review of approaches and limitations of inhalation bioavailability and bioaccessibility of metal(loid)s from ambient particulate matter or dust
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- 作者：Farzana Kastury ; farzana.kastury@mymail.unisa.edu.au" class="auth_mail" title="E-mail the corresponding author ; Euan Smith ; Albert L. Juhasz
- 关键词：Ambient particulate matter ; Inhalation bioaccessibility ; Inhalation bioavailability ; Simulated lung fluid ; Gamble ; Metal(loid)
- 刊名：Science of the Total Environment
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：574
- 期：Complete
- 页码：1054-1074
- 全文大小：966 K
文摘
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Methods for assessing metal(loid) inhalation bioaccessibility lack consistency.
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Simulated lung fluids (SLF) vary considerably.
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Particle sizes utilised are often not relevant for human inhalation exposure.
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Comparative studies illustrating the extraction efficiency of SLF are lacking.
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In vitro assays require in vivo correlation to determine predictive performance.