Clonorchis sinensis excretory-secretory products regulate migration and invasion in cholangiocarcinoma cells via extracellular signal-regulated kinase 1/2/nuclear factor-κB-dependent matrix metalloproteinase-9 expression

详细信息    查看全文

• 作者：Jhang Ho Pak^a ; Jimin Shin^b ; ^c ; In-Sung Song^b ; ^c ; Sungbo Shim^d ; Sung-Wuk Jang^b ; ^c ; ^{swjang@amc.seou.kr}
• 关键词：Clonorchis sinensis ; Cholangiocarcinoma ; Excretory&ndash ; secretory products ; Extracellular matrix ; Matrix metalloproteinase
• 刊名：International Journal for Parasitology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：47
• 期：1
• 页码：51-59
• 全文大小：1094 K
• 卷排序：47

文摘

We examined the roles of excretory–secretory products (ESPs) in cholangiocarcinoma. ESPs induced MMP-9 expression and activity in a concentration-dependent manner. ESPs induced MMP-9 expression by enhancing the activity of NF-κB through ERK1/2. ESP-dependent MMP-9 activity may contribute to cholangiocarcinoma progression.