Association of Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Variants with Ischemic Stroke and Its Subtype

详细信息    查看全文

• 作者：Xiao-Ya Huang^* ; Li-Ya Han^* ; Xiang-Dong Huang^* ; Chao-Hong Guan^* ; Xin-Lei Mao^* ; Zu-Sen Ye^&dagger ; ; ^{zusenye@163.com}
• 关键词：Ischemic stroke ; matrix metalloproteinase ; polymorphism ; stroke subtype
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：26
• 期：2
• 页码：368-375
• 全文大小：320 K
• 卷排序：26

文摘

Genetic variations in the genes of matrix metalloproteinases (MMPs) may play an important role in the pathogenesis of ischemic stroke (IS). Here we investigate the association between MMP-1 −1607 1G/2G and MMP-3 −1171 5A/6A genetic polymorphisms and etiological subtypes of IS in the Han Chinese population.MethodsA total of 640 eligible patients with IS and 637 age- and gender-matched apparently healthy volunteers were enrolled. Subtypes of IS were classified by Trial of Org 10172 in Acute Stroke Treatment criteria. MMP-1 (−1607 1G/2G) and MMP-3 (−1171 5A/6A) polymorphisms were evaluated using polymerase chain reaction-restriction fragment length polymorphism.ResultsThe frequencies of the 5A/6A + 5A/5A genotypes and 5A allele were significantly higher in patients with IS than in controls (P < .001, P < .001, respectively). No association was found between MMP-1 1G/2G polymorphism and overall IS. In subgroup analyses, MMP-1 1G/2G and 2G/2G genotypes increased the risk of small-artery occlusion (SAO) subtype (multivariate-adjusted, P < .001, P = .002, respectively), and MMP-3 5A/6A + 5A/5A genotypes were related with large-artery atherosclerosis (LAA) subtype (multivariate-adjusted, P < .001). Haplotype analyses indicated that 2G-6A and 1G-5A increased the risk of SAO (multivariate-adjusted, P = .029) and LAA (multivariate-adjusted, P < .001), respectively.ConclusionsMMP-1 (−1607 1G/2G) and MMP-3 (−1171 5A/6A) polymorphisms may contribute to different subtypes of IS susceptibility.