miR-122 promotes hepatic antioxidant defense of genetically improved farmed tilapia (GIFT, Oreochromis niloticus) exposed to cadmium by directly targeting a metallothionein gene

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• 作者：Jun Qiang^a ; ^{Qiangj@ffrc.cn} ; Yi-Fan Tao^b ; Jie He^a ; Pao Xu^a ; ^Xup@ffrc.cn ; Jin-Wen Bao^b ; Yi-Lan Sun^a
• 关键词：GIFT tilapia ; miR-122 ; Metallothionein ; Cadmium ; Antioxidant enzymes
• 刊名：Aquatic Toxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：182
• 期：Complete
• 页码：39-48
• 全文大小：971 K
• 卷排序：182

文摘

MiR-122 regulated tilapia MT by directly targeting MT 3′UTR. MiR-122 level was negatively related to MT level under Cd stress. MiR-122 silencing caused up-regulation of MT expression. MiR-122 loss relieved liver stress and stimulated antioxidant enzymes.