Inflammation of the infrapatellar fat pad

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• 作者：Florent Eymard ; ^{florent.eymard@hmn.aphp.fr" class="auth_mail" title="E-mail the corresponding author} ; Xavier Chevalier
• 关键词：Infrapatellar fat pad ; Hoffa's disease ; Inflammation ; Adipokines ; Knee osteoarthritis
• 刊名：Joint Bone Spine
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：83
• 期：4
• 页码：389-393
• 全文大小：1198 K

文摘

The infrapatellar fat pad (IFP) of Hoffa's fat pad is the main adipose structure within the knee joint. It is located between the joint capsule and the synovial membrane, which lines its posterior aspect. The IFP is composed chiefly of adipocytes and receives an abundant supply of blood vessels and nerves. Immune cells can infiltrate the IFP, which can become a major source of numerous proinflammatory mediators (cytokines and adipokines). The physiological role for the IFP remains unclear but may involve shock absorption and the protection of adjacent tissues. Hoffa's disease is characterized by inflammation, hypertrophy, and fibrosis of the pad in response to repetitive trauma. Anterior knee pain is the most common symptom. In advanced forms, metaplasia of the IFP may result in the development of a sometimes sizable osteochondroma. The IFP may also contribute to the pathophysiology of knee osteoarthritis, in particular via procatabolic and proinflammatory effects on its synovial lining. Finally, in patients with knee osteoarthritis, inflammation of the IFP may be a source of pain.