Added value of combined 18F-FDG PET/CT for detection of osseous metastases in cancer patients

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• 作者：Susan Adil Ali ; ^{Dr.susanadil@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Yasser Ibrahim Abd Elkhalek ^{yasserib77@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CT ; 18F-PET/CT ; Osseous metastases
• 刊名：The Egyptian Journal of Radiology and Nuclear Medicine
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：47
• 期：2
• 页码：453-458
• 全文大小：893 K

文摘

The goal of the study was to illustrate the added value of combined 18F-FDG PET/CT over isolated CT for detection of osseous metastases in cancer patients.

Patients and methods

The study included 53 patients divided into five groups of primary malignancies. 18F-PET/CT scans were performed. In this study, a lesion based analysis was performed in detailed retrograde matter for a total of 386 detected osseous lesions on CT and fused images of 18F-PET/CT. Statistical analysis including specificity, Sensitivity, negative predictive value (NPV) and positive predictive value (PPV) of each of these modalities was calculated. A final diagnosis of metastasis was confirmed by biopsy or by further clinical and radiologic workup.

Results

According to lesion based analysis, the 18F-PET/CT showed 100% sensitivity, 80.8% specificity, 98.6% PPV, 100% NPV and 98.7% accuracy compared with 93.9%, 34.6%, 95.2%, 29% and 89.9%, respectively, for CT. Significant improvement of the sensitivity and specificity was found in combined 18F-PET/CT than in CT alone.

Conclusion

Combined 18-F FDG PET/CT significantly improves the sensitivity and specificity of isolated CT for the detection of osseous metastases.