Distant soft-tissue metastases (subcutaneous tissues and skeletal
muscle) are extremely rare, specially in esophageal carcinoma. We describe a patient who was treated for oesophageal adenocarcinoma 2.5 years before. A PET/CT was performed showing metastatic spread because of a solitary focus of increased tracer uptake corresponding one subcutaneous node in the upper abdomen. An excisional biopsy proved to be a
metastasis from the carcinoma. Restaging
18F-FDG PET/CT study was performed 2 years later demonstrating some focus of increased uptake within several
muscles as isolated distant hematogenous spread of metastases, as they were histopathologically confirmed.
As most of soft-tissue metastases are asymptomatic, the physicians should recommend histopathological study of focus of FDG uptake at subcutaneous tissues and/or skeletal muscles, because they may be the first sign of disease expansion so therapeutic management of these patients could be changed.