7-Aminoclonazepam is superior to clonazepam for detection of clonazepam use in oral fluid by LC-MS/MS
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- 作者：Stacy E.F. Melansona ; semelanson@partners.org" class="auth_mail" title="E-mail the corresponding author ; David Griggsb ; Ida Bixhoa ; Tahira Khaliqb ; James G. Floodb
- 关键词：CLON ; clonazepam ; 7AC ; 7-aminoclonazepam ; OF ; oral fluid ; BZ ; benzodiazepine ; LC&ndash ; MS/MS ; liquid chromatography&ndash ; tandem mass spectrometry ; MDMA ; 1 ; 3-methylenedioxy-methamphetamine ; MS ; mass spectrometry ; OXAZ ; oxazepam ; PRN ; pro re nata or when necessary
- 刊名：Clinica Chimica Acta
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：455
- 期：Complete
- 页码：128-133
- 全文大小：459 K
文摘
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OF is becoming increasingly popular as a tool to monitor compliance in the addiction setting.
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CLON can be challenging to measure in OF due to its presence in low concentrations.
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We demonstrate that 7AC is superior to CLON for monitoring CLON use.
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Clinically, 7AC is superior to CLON for detection of both CLON compliance and undisclosed use.
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Laboratories performing OF testing should validate and implement 7AC in OF for the assessment of CLON use.