Pentylenetetrazole (PTZ)- induced kindled rats are associated with impairment of memory and oxidative stress.
S-adenosyl methionine (SAM) had antiepileptic property in PTZ- induced kindling model in rats.
SAM prevents memory impairment in PTZ- induced kindling model.
Memory enhancing potential of SAM could be due to its antioxidant property.
Antioxidant and memory enhancing property of SAM could have beneficial role in the treatment of epilepsy.