Methionine enkephalin regulates microglia polarization and function
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- 作者：Xuxu Xua ; Yan Gaoa ; Lulu Wena ; Zhiyong Zhaia ; Shuo Zhanga ; Fengping Shanb ; Juan Fenga ; cmufengjuan@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Arg1 ; arginase-1 ; CNS ; central nervous system ; CAMK ; Ca2 ; +/calcineurin-dependent protein kinase ; DCs ; dendritic cells ; DMEM ; Dulbecco's modified Eagle medium ; ELISA ; enzyme-linked immunosorbent assay ; FCM ; flow cytometry ; IFN-γ ; interferon-γ ; iNOS ; inducible NO synthase ; LPS ; lipopolysaccharide ; MENK ; methionine enkephalin ; NO ; nitric oxide ; OD ; optical density ; ROS ; reactive oxygen&ndash ; nitrogen species ; TLR ; toll-like receptor
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：90-97
- 全文大小：735 K
文摘
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MENK therapy induced up-regulation of CD86, CD40, IL-12, and TNF-α, but had no effect on CD163, IL-10, and TGF-β.
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A high phagocytosis capacity and increased expression of ROS, nitrite and iNOS were observed in MENK-treated microglia.
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Supernatants from MENK-treated microglia induced cytotoxicity against glioblastoma cells.