Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine β-synthase
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- 作者：Joã ; o B. Vicentea ; jvicente@itqb.unl.pt" class="auth_mail" title="E-mail the corresponding author ; Francesca Malagrinò ; b ; Marzia Areseb ; Elena Forteb ; Paolo Sartib ; Alessandro Giuffrè ; c ; alessandro.giuffre@uniroma1.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：H2S ; hydrogen sulfide ; NO ; nitric oxide ; CO ; carbon monoxide ; CcOX ; cytochrome c oxidase ; CBS ; cystathionine β-synthase ; AdoMet ; S-adenosyl-l-methionine ; CGL ; cystathionine γ-lyase ; PLP ; pyridoxal 5&prime ; -phosphate ; MST ; 3-mercaptopyruvate sulfurtransferase ; CAT ; cysteine aminotransferase ; 3-MP ; 3-mercaptopyruvate ; SOU ; sulfide oxidizing unit ; SQR ; sulfide ; quinone oxidoreductase ; GSH ; reduced glutathione ; GSSH ; glutathione persulfide ; ETHE1 ; persulfide dioxygenase ; Rhod ; rhodanese ; SOx ; sulfite
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1857
- 期：8
- 页码：1127-1138
- 全文大小：1611 K
文摘
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The gasotransmitters H2S, NO and CO all inhibit cytochrome c oxidase.
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At low levels H2S can also act as a substrate for mitochondrial respiration.
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Bioenergetic effects depend on availability of H2S and its interplay with NO and CO.
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H2S synthesis by cystathionine β-synthase is effectively inhibited by CO and NO.
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These newly discovered regulatory mechanisms are herein reviewed.