Emerging Skin T-Cell Functions in Response to Environmental Insults

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• 作者：Jutamas Suwanpradid¹ ; Zachary E. Holcomb¹ ; ² ; Amanda S. MacLeod¹ ; ³ ; ⁴ ; ^{Amanda.MacLeod@duke.edu}
• 关键词：APC ; antigen-presenting cell ; CHS ; contact hypersensitivity ; CLA ; cutaneous lymphocyte-associated antigen ; DETC ; dendritic epidermal T cell ; FDE ; fixed drug eruption ; TCM ; central memory T cell ; TEFF ; effector T cell ; Th ; T helper ; TREG ; regulatory T cell ; TRM ; tissue-resident memory T cell
• 刊名：Journal of Investigative Dermatology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：137
• 期：2
• 页码：288-294
• 全文大小：347 K
• 卷排序：137

文摘

Skin is the primary barrier between the body and the outside world, functioning not only as a physical barrier, but also as an immunologic first line of defense. A large number of T cells populate the skin. This review highlights the ability of these cutaneous T cells to regulate skin-specific environmental threats, including microbes, injuries, solar UV radiation, and allergens. Since much of this knowledge has been advanced from murine studies, we focus our review on how the mouse state has informed the human state, emphasizing the key parallels and differences.