2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H2O2-dependent JNK activation in cancer cells
详细信息 查看全文
- 作者：Wen Suna ; Jiaolin Baoa ; Wei Lina ; Hongwei Gaoa ; Wenwen Zhaoa ; Qingwen Zhanga ; Chung-Hang Leunga ; Dik-Lung Mab ; Jinjian Lua ; Xiuping Chena ; xpchen@umac.mo" class="auth_mail" title="E-mail the corresponding author
- 关键词：CAT ; catalase ; DAF-FM ; 4-amino-5-methylamino-2&prime ; 7&prime ; -mifluorofluorescein ; DCFH2-DA ; 2&prime ; 7&prime ; -dichlorodihydrofluorescein diacetate ; DHE ; dihydroethidium ; DMSO ; dimethyl sulfoxide ; DPI ; diphenyleneiodonium ; ERK ; extracellular signal regulated kinase ; FLR ; fluorescence detector ; HPLC ; high-performance liquid chromatography ; HROS ; highly reactive oxygen species ; HPF ; hydroxyphenyl fluorescein ; iNOS ; Inducible nitric oxide synthase ; JC-1 ; 5 ; 5&prime ; 6 ; 6&prime ; -tetrachloro-1 ; 1&prime
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：61-77
- 全文大小：5417 K
文摘
- •
MAM, a natural naphthoquinone, induces multiple forms of cancer cells death including necroptosis and apoptosis.
- •
NO-dependent cell death was mediated by JNK signaling activated through H2O2 generation in MAM-treated cancer cells.
- •
MAM-induced ROS generation is mediated by GSH depletion, which plays an initial role in MAM’s cytotoxicity.