Chemical investigation of the roots of Polygala sibirica L.

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• 作者：Yu-Hong ZHOU^a ; ^# ; Shui-Ying ZHANG^b ; ^# ; Qiang GUO^b ; Xing-Yun CHAI^b ; Yong JIANG^a ; ^{yongjiang@bjmu.edu.cn" class="auth_mail} ; Peng-Fei TU^a ; ^b ; ^{pengfeitu@vip.163.com" class="auth_mail}
• 关键词：Polygala sibirica ; Polygalaceae ; Sibiricose A7 ; Sibiriphenone A
• 刊名：Chinese Journal of Natural Medicines
• 出版年：March, 2014
• 年：2014
• 卷：12
• 期：3
• 页码：225-228
• 全文大小：341 K

文摘

Aim

To investigate the chemical constituents of the roots of Polygala sibirica L. (Polygalaceae)

Method

The isolation was performed by solvent extraction and various chromatographic techniques, including silica gel, Sephadex LH-20, ODS, semi-preparative HPLC, and preparative TLC. The chemical structures were elucidated based on extensive spectroscopic analysis, including HR-ESI-MS and 1D- and 2D-NMR spectroscopic data.

Results

A total of sixteen compounds, including five xanthones (5, 7-10), five saccharide esters (1, 3, 4, 12, 13), two flavonoids (14, 16), two triterpenoids (11, 15), one phenylpropanoid (6), and one benzophenone glycoside (2) were isolated. Their structures were determined as sibiricose A7 (1), sibiriphenone A (2), polygalatenoside A (3), polygalatenoside C (4), lancerin (5), 3, 4, 5-trimethoxycinnamic acid (6), 6-hydroxy-1, 2, 3, 7-tetramethoxyxanthone (7), 1, 3, 7-trihydroxy-2-methoxyxanthone (8), onjixanthone II (9), 1, 2, 3, 6, 7-pentamethoxyxanthone (10), presenegenin (11), 3鈥?O-3, 4, 5-trimethoxycinnamoyl-6-O-4-methoxy benzoyl sucrose (12), tenuifoliside C (13), 5, 3鈥?dihydroxy-7, 4鈥?dimethoxyflavonol-3-O-尾-D-glucopyranoside (14), tenuifolin (15), and rhamnetin 3-O-尾-D-glucopyranoside (16).

Conclusion

Compounds 1 and 2 are two new compounds from P. sibirica.