Anti-ulcer xanthones from the roots of Hypericum oblongifolium Wall

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• 作者：Mumtaz Ali^a ; ^{mumtazphd@gmail.com" class="auth_mail} ; Abdul Latif^a ; ^{dralatif@uom.edu.pk" class="auth_mail} ; Khair Zaman^b ; Mohammad Arfan^c ; Derek Maitland^d ; Habib Ahmad^e ; Manzoor Ahmad^a
• 关键词：Hypericum oblongifolium Wall ; Xanthones ; Hypericorin C ; Hypericorin D ; 2D-NMR ; Anti-ulcer
• 刊名：Fitoterapia
• 出版年：June 2014
• 年：2014
• 卷：95
• 期：Complete
• 页码：258-265
• 全文大小：449 K

文摘

Three new xanthones, hypericorin C (1), hypericorin D (2) and 3,4-dihydroxy-5-methoxyxanthone (3), along with eight known compounds; 2,3-dimethoxyxanthone (4), 3,4-dihydroxy-2-methoxyxanthone (5), 3,5-dihydroxy-1-methoxyxanthone (6), 3-acetylbetulinic acid (7), 10H-1,3-dioxolo[4,5-b]xanthen-10-one (8), 3-hydroxy-2-methoxyxanthone (9), 3,4,5-trihydroxyxanthone (10) and betulinic acid (11) were isolated from the roots of Hypericum oblongifolium. The structures of the new compounds 1, 2 and 3 were deduced by spectroscopic techniques [ESI MS, ¹H NMR, ¹³C NMR, and 2D NMR (HMQC, HMBC, COSY and NOESY)]. The entire series of compounds were evaluated for anti-ulcer activity.