A novel preparation of methyl-β-cyclodextrin from dimethyl carbonate and β-cyclodextrin

详细信息    查看全文

• 作者：Yongjiang Gan^a ; ^b ; Yimin Zhang^a ; ^c ; ^{zhangym001@263.net} ; Chuanhao Xiao^b ; Chunyan Zhou^a ; Yucang Zhao^b
• 关键词：&#x3b2 ; -Cyclodextrin ; Dimethyl carbonate ; Methyl-&#x3b2 ; -cyclodextrin ; NMR ; MS
• 刊名：Carbohydrate Research
• 出版年：2011
• 出版时间：15 February 2011
• 年：2011
• 卷：346
• 期：3
• 页码：389-392
• 全文大小：272 K

文摘

A novel green synthesis process about methyl-β-cyclodextrin has been investigated through the reaction between β-cyclodextrin and dimethyl carbonate by anhydrous potassium carbonate as catalyst in DMF. The influence of experimental factors including the molar ratio of dimethyl carbonate to β-cyclodextrin, reaction temperature, and reaction time on the average degree of substitution of methyl-β-cyclodextrin was studied. The results show that the average degree of substitution of methyl-β-cyclodextrin can be dependent on the reaction temperature and the molar ratio of raw material primarily. The structures of methyl-β-cyclodextrin were characterized by TLC, IR, MS, ¹H NMR, and ¹³C NMR.