Lysosomal cell death mechanisms in aging

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• 作者：Raquel Gó ; mez-Sintes^a ; Marí ; a Dolores Ledesma^b ; Patricia Boya^a ; ^{pboya@cib.csic.es}
• 关键词：3-MA ; 3-methyladenine ; 6-OHDA ; 6-hydroxydopamine ; AD ; Alzheimer&rsquo ; s disease ; AIF ; apoptosis inducing factor ; ALR ; autophagosome-lysosome reformation ; ALS ; amyotrophic lateral sclerosis ; AMD ; age- dependent macular degeneration ; ApoE ; apolipoprotein E ; APP ; amyloid precursor protein ; ASM ; acid sphingomyelinase ; ATP13A2 ; ATPase Type 13A2 ; Aβ ; β-amyloid ; Baf A ; bafilomycin A ; BMP ; bis(monoacylglycero) phosphate ; BPC ; biphosphinic palladacycle complex ; CD3 ; cluster of differentiation 3 receptor
• 刊名：Ageing Research Reviews
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：32
• 期：Complete
• 页码：150-168
• 全文大小：2779 K
• 卷排序：32

文摘

Lysosomal cell death participates in physiological processes, aging, and disease. Lysosomal membrane permeabilization plays a key role in lysosomal cell death. Inducers and inhibitors of lysosomal cell death may be of therapeutic value.