New C-methylated flavonoids and α-pyrone derivative from roots of Talinum triangulare growing in Nigeria

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• 作者：Blessing O. Umeokoli^a ; ^b ; Rini Muharini^a ; Festus B. Okoye^b ; Vincent I. Ajiwe^c ; Mabel U. Akpuaka^c ; Wenhan Lin^d ; Zhen Liu^a ; ^{zhenfeizi0@sina.com" class="auth_mail" title="E-mail the corresponding author} ; Peter Proksch^a ; ^{proksch@uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Talinum triangulare ; C-methylated flavonoids ; α-pyrone ; Amides
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：109
• 期：Complete
• 页码：169-173
• 全文大小：440 K

文摘

The first chemical examination of roots of the traditionally used medicinal plant Talinum triangulare (Portulacaceae) from Nigeria led to the isolation of two new C-methylated flavonoids, 5,6-dimethoxy-7-hydroxy-8-methyl-flavone (class="boldFont">1), 5,6-dimethoxy-8-methyl-2-phenyl-7H-1-benzopyran-7-one (class="boldFont">2), and one new α-pyrone derivative, 4-methoxy-6-(2-hydroxy-4-phenylbutyl)-2H-pyran-2-one (class="boldFont">3), along with thirteen known compounds, including nine amides (class="boldFont">4–class="boldFont">12), indole-3-carboxylic acid (class="boldFont">13), p-hydroxy benzoic acid (class="boldFont">14), and two steroids (class="boldFont">15–class="boldFont">16). Their structures were elucidated by extensive spectroscopic measurements including 1D, 2D NMR, MS, and by comparison with the literature. All isolated compounds were screened for their cytotoxic and antifungal activities. However, none of them showed significant activity.