Biochemistry and regulation of the protein arginine methyltransferases (PRMTs)
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- 作者：Yalemi Morales ; Tamar Cá ; ceres ; Kyle May ; Joan M. Hevel ; Joanie.Hevel@usu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Arginine methylation ; Protein arginine methyltransferase ; PRMT ; Monomethylarginine ; Dimethylarginine ; S-adenosyl methionine
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：590
- 期：Complete
- 页码：138-152
- 全文大小：2499 K
文摘
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Protein arginine methyltransferases (PRMTs) methylate protein arginyl groups.
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PRMT substrates of nine mammalian isoforms show no consensus sequence.
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PRMTs can form monomethyl-, asymmetric dimethyl- or symmetric dimethylarginine.
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Biological function is dependent upon specific product formation.
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Processivity, regulators and posttranslational modifications control activity.