The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention
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- 作者：Alex J. Fulchera ; b ; Haran Sivakumaranc ; d ; Hongping Jinc ; Daniel J. Rawlec ; e ; David Harrichc ; f ; David A. Jansa ; g ; David.Jans@monash.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nucleolar trafficking ; Methyltransferase PRMT6 ; HIV-1 Tat ; HIV-1 Rev ; HTLV-1 Rex
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1863
- 期：2
- 页码：254-262
- 全文大小：1351 K
文摘
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First report of nuclear to nucleolar trafficking being regulated by methylation
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First report that Tat methylation by PRMT6 can inhibit nucleolar retention
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Delineate methylation sites/methylase responsible for Tat nucleolar regulation