A Tale of Two Cities: How Xist and its partners localize to and silence the bicompartmental X
详细信息 查看全文
- 作者：Stefan F. Pinter ; spinter@uchc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：XCI ; X chromosome inactivation ; GRO-UP ; Genome ReOrganization Upon Pluripotency-exit ; ncRNA ; non-coding RNA ; Xi ; inactive X ; Xa ; active X ; RNAPII ; RNA polymerase II ; H2A ; histone H2A ; H3 ; histone 3 ; H4 ; histone 4 ; H2AK119ub ; H2A lysine 119 mono-ubiquitination ; H3K27me3 ; H3 lysine 27 tri-methylation ; H4K20me1 ; H4 lysine 20 mono-methylation ; H3K9me2/3 ; H3 lysine 9 di/tri-methylation ; H3K4me3 ; H3 lysine 4 tri-methylation ; H3K36me3 ; H3 lysine 36 tri-methylation ; H3K27ac ; H3 lysine 27 acetylation ; H3
- 刊名：Seminars in Cell & Developmental Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：19-34
- 全文大小：1961 K
文摘
- •
Collapse of active nuclear compartment by Xist RNA binding HnrnpU, evicting RNAPII.
- •
Genome ReOrganization Upon Pluripotency-exit (GRO-UP) acts on Xa/Xi, parallel to XCI.
- •
GRO-UP silences gene-poor, LINE1-rich DNA while Xist localizes to gene-rich islands.
- •
Xist recruits Spen for initial gene silencing, locked in by PRC1/2 and/or macroH2A.
- •
Smchd1 compacts the hypoacetylated Xi across mutually reinforcing H3K9me2/3 & H3K27me3 domains.