Genetic and epigenetic variants in the MTHFR gene are not associated with non-Hodgkin lymphoma
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- 作者：Gabrielle Bradshaw ; Heidi G. Sutherland ; Emily T. Camilleri ; Rodney A. Lea ; Larisa M. Haupt ; Lyn R. Griffiths ; lyn.griffiths@qut.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bp ; base pairs ; CGIs ; CpG Islands ; CIMP ; CpG island methylator phenotype ; DLBCL ; diffuse large b-cell lymphoma ; DNA ; deoxyribose nucleic acid ; EDTA ; ethylenediaminetetra acetic acid ; FL ; follicular lymphoma ; HRM ; high resolution melt ; MTHFR ; methylenetetrahydrofolate reductase ; NHL ; non-Hodgkin lymphoma ; OR ; odds ratio ; PCR ; polymerase chain reaction ; RFLP ; restriction fragment length polymorphism ; SD ; standard deviation ; SNP ; single nucleotide polymorphism ; THF ; tetrahydrofolate ; WHO ; World Hea
- 刊名：Meta Gene
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：6
- 期：Complete
- 页码：91-95
- 全文大小：273 K
文摘
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The MTHFR gene codes for the MTHFR enzyme which plays a key role in folate and methionine metabolism
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Polymorphisms affect its regulation and have been linked to lymphoma
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No significant differences were observed between genotype or allele frequencies for two functional MTHFR polymorphisms
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MTHFR promoter methylation is not an epigenetic biomarker for NHL diagnosis or prognosis in peripheral blood samples