Solid Phase Synthesis of Peptide Hydroxamic Acids

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• 作者：Chen ; Jack J. ; Spatola ; Arno F.
• 刊名：Tetrahedron Letters
• 出版年：1997
• 出版时间：March 3, 1997
• 年：1997
• 卷：38
• 期：9
• 页码：1511-1514
• 全文大小：223 K

文摘

The synthesis of peptide hydroxamic acids has been performed on a solid support. A carboxyl group of a peptide synthesized on para-methylbenzhydrylamine (pMBHA) resin was converted to a hydroxamate functional group by condensing with NH₂OBzl, which was found preferable to NH₂OtBu or NH₂OTrt. The hydroxamate benzyl protecting group was removed subsequently during HF cleavage of the peptide resin. Five peptide hydroxamic acids were prepared according to this new method.