Preparation of MBHA resin by benzotriazole-mediated amidoalkylation

详细信息    查看全文

• 作者：Tae-Kyung Lee ; Jeong-Hyun Choi ; Jang-Woong Byun ; Yoon-Sik Lee
• 关键词：MBHA resin ; Amidoalkylation ; 1-Benzotriazole ; Solid-phase peptide synthesis
• 刊名：Tetrahedron Letters
• 出版年：2008
• 出版时间：8 September 2008
• 年：2008
• 卷：49
• 期：37
• 页码：5380-5382
• 全文大小：191 K

文摘

MBHA (4-methylbenzhydrylamine) resin is widely used as a solid support for the synthesis of carboxamides or peptide C-terminal amides. Herein, we report a new method for synthesizing MBHA resin by benzotriazole-mediated amidoalkylation. MBHA resin was efficiently prepared with N-[(benzotriazol-1-yl)(p-tolyl)methyl]formamide or N-[formamido(p-tolyl)methyl]formamide, and it showed excellent properties as a solid support.