Preparation of a core–shell type MBHA resin and its application for solid-phase peptide synthesis

详细信息    查看全文

• 作者：Jeong-Hyun Choi ; Tae-Kyung Lee ; Jang-Woong Byun ; Yoon-Sik Lee
• 关键词：MBHA resin ; Core– ; shell-type resin ; α ; -Amidoalkylation ; Partial hydrolysis ; Solid-phase peptide synthesis
• 刊名：Tetrahedron Letters
• 出版年：2009
• 出版时间：22 July 2009
• 年：2009
• 卷：50
• 期：29
• 页码：4272-4275
• 全文大小：349 K

文摘

MBHA (4-methylbenzhydrylamine) resin has been extensively used as a solid support for the synthesis of peptide amides. Herein, we prepared the core–shell-type MBHA resin by benzotriazole-catalyzed amidoalkylation and partial hydrolysis. The core–shell structure of the MBHA resin was confirmed by two-photon microscopy and its synthetic performance in solid-phase peptide synthesis (SPPS) was evaluated.