Ultrashort cationic lipopeptides and lipopeptoids: Evaluation and mechanistic insights against epithelial cancer cells
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- 作者：Ronald Domalaona ; Brandon Findlaya ; Makanjuola Ogunsinaa ; Gilbert Arthurb ; Frank Schweizera ; c ; schweize@cc.umanitoba.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMP ; antimicrobial peptide ; USCL ; ultrashort cationic lipopeptide ; Fmoc ; fluorenylmethyloxycarbonyl ; MBHA ; 4-methylbenzhydrylamine ; TFA ; trifluoroacetic acid ; DMEM ; Dulbecco&rsquo ; s Modified Eagle&rsquo ; s Medium ; FBS ; fetal bovine serum ; MTS ; (3-(4 ; 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) ; PES ; phenazine ethosulfate ; OD ; optical density ; Q-VD-OPh ; N-(2-quinolyl)-l-valyl-l-aspartyl-(2 ; 6-difluorophenoxy) methylketone ; EthD-1 ; ethidium homodimer-1 ; ANOVA
- 刊名：Peptides
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：58-67
- 全文大小：2122 K
文摘
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The discovery of ultrashort cationic lipopeptides that possess promising anticancer activity is outlined.
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The synthesized lipopeptides do not eradicate cancer cells via cell lysis or necrosis.
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Ultrashort cationic lipopeptides may elicit different mechanism of cancer cell killing either by caspase-dependent apoptosis or caspase-independent cell death.