Ala5-galanin (2-11) is a GAL2R specific galanin analogue
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- 作者：Kristin Weblinga ; kristin.webling@neurochem.su.se" class="auth_mail" title="E-mail the corresponding author ; Johan Runessona ; Andreas Langb ; Indrek Saarc ; Barbara Koflerb ; Ü ; lo Langela ; c
- 关键词：BBB ; blood-brain barrier ; CHO cells ; Chinese hamster ovary cells ; CNS ; central nervous system ; EDTA ; ethylenediaminetetraacetic acid ; FBS ; fetal bovine serum ; Fmoc ; 9-fluorenylmethyloxycarbonyl ; FSK ; forskolin ; GAL1R ; Galanin receptor 1 ; GAL2R ; Galanin receptor 2 ; GAL3R ; Galanin receptor 3 ; GIP ; GPCR interacting proteins ; GPCRs ; G-protein coupled receptors ; HKR ; HEPES buffered Krebs-Ringer solution ; HPLC ; high performance liquid chromatography ; IP ; inositol phosphate ; MBHA ; p-methylbenzhydrylami
- 刊名：Neuropeptides
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：60
- 期：Complete
- 页码：75-82
- 全文大小：617 K
文摘
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Ala5-galanin (2–11) is the shortest galanin receptor 2 specific agonist reported.
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Classical second messenger assays were compared to real-time label-free techniques for GPCR signaling.
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The importance of Ser5 for GAL3R binding from an in silico study were experimentally verified.