Statin-induced chronic cholesterol depletion inhibits Leishmania donovani infection: Relevance of optimum host membrane cholesterol
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- 作者：G. Aditya Kumara ; 1 ; Saptarshi Royb ; 1 ; Md. Jafurullaa ; Chitra Mandalb ; cmandal@iicb.res.in" class="auth_mail" title="E-mail the corresponding author ; Amitabha Chattopadhyaya ; amit@ccmb.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：FCS ; fetal calf serum ; FITC ; fluorescein isothiocyanate ; MβCD ; methyl-β-cyclodextrin ; HMG-CoA reductase ; 3-hydroxy-3-methylglutaryl coenzyme A reductase ; MTT ; 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyl-tetrazolium bromide ; TLC ; thin layer chromatography ; VL ; visceral leishmaniasis
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1858
- 期：9
- 页码：2088-2096
- 全文大小：1118 K
文摘
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Leishmanial entry reduces on chronic host membrane cholesterol depletion by statin.
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Enriched host membrane cholesterol results in reduction in the entry of Leishmania.
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Entry of E. coli remains invariant with modulation of host membrane cholesterol.
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Optimum host membrane cholesterol is crucial for leishmanial entry.