Decapping Scavenger (DcpS) enzyme: Advances in its structure, activity and roles in the cap-dependent mRNA metabolism
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- 作者：Adina L. Milaca ; Elzbieta Bojarskab ; elab@biogeo.uw.edu.pl" class="auth_mail ; Anna Wypijewska del Nogalb ; wypijewska.del.nogal@gmail.com" class="auth_mail
- 关键词：Aptx ; APraTaXin ; ARCA ; Anti-Reverse Cap Analog ; A. suum ; Ascaris suum ; CBC ; Cap-Binding Complex ; C. elegans ; Caenorhabditis elegans ; Dcp2 ; Decapping protein 2 ; DcpS ; Decapping Scavenger ; eIF4E ; eukaryotic translation Initiation Factor 4E ; Fhit ; Fragile HIstidine Triad ; Fre1 ; C. elegans Flavin Reductase 1 ; GalT ; GALactose-1-P uridylylTransferase ; Hint ; HIstidine triad NucleoTide-binding ; HIT ; Histidine Triad ; m7GDP ; 7-methylguanosine diphosphate ; m7GMP ; 7-methylguanosine monophosphate ; m7GTP ; 7-m
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：June 2014
- 年：2014
- 卷：1839
- 期：6
- 页码：452-462
- 全文大小：1518 K
文摘
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Recent advances in the structure and activity of Decapping Scavenger (DcpS) enzyme;
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Evaluation of DcpS roles in the cap-dependent mRNA metabolism;
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Discussion of potential approaches to the SMA treatment based on DcpS inhibitors;
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Overview of DcpS enzymes from different species: human, mouse, nematode and yeast.