Synthesis and characterization of chitosan-based hydrogels
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- 作者：Qianzhu Li ; Dongzhi Yang ; Guiping Ma ; Qiang Xu ; Xiangmei Chen ; Fengmin Lu ; Jun Nie
- 关键词：Biocompatible ; Chitosan ; Photocrosslinking
- 刊名：International Journal of Biological Macromolecules
- 出版年：2009
- 出版时间：1 March 2009
- 年：2009
- 卷：44
- 期：2
- 页码：121-127
- 全文大小：1121 K
文摘
Biocompatible hydrogels based on water-soluble chitosan–ethylene glycol acrylate methacrylate (CS–EGAMA) and polyethylene glycol diamethacrylate (PEGDMA) were synthesized by photopolymerization. Characterization of morphology, weight loss, water state of hydrogel, pH-sensitivity and cytotoxicity were investigated by scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), swelling test and methylthiazolydiphenyl-tetrazolium bromide (MTT) assay. The results indicated that the hydrogels were sensitive to pH of the medium, no cytotoxicity for L929 and SW1353, satisfactory for the composite to be used in bioapplications.