- 作者：A. Hakan Vural ; Serhat Yalcinkaya ; Tamer Tü ; rk ; Gü ; ndü ; z Yü ; mü ; n ; Nihal Gü ; l ; Ulviye Yalcinkaya ; Metin Kaya ; Ahmet Ö ; zyazicioğ ; lu
- 关键词：endothelium ; shunts ; off-pump ; CABG ; surgery
- 刊名：Journal of Surgical Research
- 出版年：2008
- 出版时间：December 2008
- 年：2008
- 卷：150
- 期：2
- 页码：261-265
- 全文大小：1005 K
Background
During off-pump coronary bypass grafting, local vascular control of the target vessel and a bloodless field are crucial. The aim of this study is to asses the histopathological outcomes of intracoronary shunts and bulldog clamping on the beating heart in a canine model.Methods
Twelve healthy adult mongrel dogs weighing between 15 to 25 kg were included in the study. Following left thoracotomy, proximal left anterior descending artery segment 1 cm to distal of diagonal branch was marked. Arteriotomy at this site was performed and a shunt was inserted for 10 min in the shunt group. The bulldog clamp was applied 3 cm distal to the mark for 10 min after heparinization in the bulldog group.
Thirty days after the procedure, the specimens of left anterior descending artery from both regions were collected and were examined. Vascular damage, presence of intimal hyperplasia, and denudation were noted.
Results
Only intimal denudation was found significantly higher in the shunt group (P < 0.05). In this group, only one case had grade 0 endothelial damage. In the bulldog group, all cases had endothelial damage of various grades.
Conclusion
The proven advantages of temporary intracoronary shunts are well-known, e.g., preserving the ventricular functions. Despite these advantages, our study revealed an ultimate bad result for an off-pump coronary by pass patient: intimal denudation. We conclude that further studies with a larger number of subjects are needed to decide whether routine shunt insertion into coronary arteries during off-pump coronary bypass surgery is appropriate or not.