Surface area is the biologically most effective dose metric for acute nanoparticle toxicity in the lung
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- 作者：Otmar Schmida ; b ; otmar.schmid@helmholtz-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Tobias Stoegera ; b
- 关键词：Nanoparticle toxicity ; Lung Inflammation ; Dose&ndash ; response ; Surface area ; Dose metric ; In vivo animal model
- 刊名：Journal of Aerosol Science
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：133-143
- 全文大小：845 K
文摘
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Surface area is the most relevant dose metric for acute nanoparticle lung toxicity.
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Surface area allows identification of size-independent, material-specific nanotoxicity classes.
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Many transition metals are more toxic than carbonaceous material and metal oxide.
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Number is the most relevant dose metric for long, stiff fiber-like particles.
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Volume might be a relevant dose metric for extremely high particle lung burden.